Testing for Clostridioides difficile and its disease

C. difficile causes 5-15% of hospital-acquired diarrheas and a growing number of community acquired diarrheas.  The infection can also be asymptomatic with carriage occurring frequently.  Each testing method has its strengths and weaknesses, but a multistep algorithm combines the sensitivity of a screen with the specificity of a toxin test to optimize patient care, minimize overdiagnosis, and support antibiotic stewardship.

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